ea0070aep621 | Pituitary and Neuroendocrinology | ECE2020
Regazzo Daniela
, Barbot Mattia
, Ceccato Filippo
, Nora Albiger
, laura lizzul
, Fiorella Calabrese
, Federico Rea
, Andrea Zuin
, Boscaro Marco
, Occhi Gianluca
, Carla Scaroni
Ectopic Cushing syndrome (EAS) is a rare condition characterized by ACTH-dependent hypercortisolism resistant to normal physiologic suppression by glucocorticoids. EAS is due to an extra-pituitary tumor producing bioactive molecules generated by post-translational cleavage of the proopiomelanocortin gene (POMC). EAS is associated with significant morbidity and mortality and although surgical resection of the primary ACTH-producing tumor remains the mainstay of therapy, not all...